Robert Perneczky conducts dementia prevention research at the University of Munich and Imperial College London. His studies apply a range of methodologies to advance the understanding of biological and clinical processes that lead to cognitive decline and associated disability. This includes imaging, fluid biomarker, genomics and cognitive assessments in clinical and epidemiological contexts. The concept of cognitive reserve has always been in the centre of Robert’s scientific activities, because of the great relevance for reducing dementia risk in the population and strengthening vulnerable individuals’ resilience against neurodegeneration. Robert is Professor and Head of Geriatric Psychiatry and Director of the Alzheimer’s Memorial Center at the University of Munich, and he leads several large dementia studies and initiatives in Germany and the UK.